The drug is excreted mainly in the urine, largely as inactive metabolites and little amounts of free of charge and conjugated morphine. Negligible quantities of codeine and its metabolites are present in the feces.
Caution really should be exercised when promethazine hydrochloride and codeine phosphate syrup is administered to the nursing woman.
It might sometimes close up the bronchial tubes (air passages in the lungs) and make respiratory complicated. When codeine is applied for a very long time or in huge doses, it could turn into routine-forming, causing mental or Bodily dependence. Actual physical dependence may cause withdrawal Unwanted side effects when you instantly end having the drugs. This medication is offered only with all your medical doctor's prescription. This item is obtainable in the subsequent dosage sorts:
Drop off any unused narcotic medication at a drug take-back again site immediately. If you do not Possess a drug consider-back site in your area, flush any unused narcotic drugs down the bathroom.
Narcotic analgesics result in histamine release, which seems for being answerable for wheals or urticaria occasionally viewed at the site of injection on parenteral administration.
This is simply not a complete listing of doable Unwanted side effects. Should you detect other side effects not listed higher than, Get in touch with your medical professional or pharmacist.
Precise research to check the action of the drug on parturition, lactation, and growth on the animal neonate weren't done, but a common preliminary review in rats indicated no impact on these parameters.
Decrease Seizure Threshold – Promethazine may lower seizure threshold. It ought to be applied with caution in folks with seizure disorders or in people that are making use of concomitant prescription drugs, for instance narcotics or regional anesthetics, which may also have an affect on seizure threshold.
Prior to having this medication, inform your physician or pharmacist if you are allergic to promethazine or to dextromethorphan; or to any other phenothiazines (such as prochlorperazine); or Should you have every other allergies.
“I'm able to likely commence expressing no to scaled-down roles or points I feel usually are not contributing Promethazine codeine syrup on the larger sized Tale.
Using this drugs with any of the next medicines isn't proposed. Your medical doctor might make a decision not to treat you using this medication or adjust some of the other medicines you're taking.
When employed for an prolonged time, this medication may not work too and should demand different dosing. Talk to your health care provider if this medication stops Functioning properly.
The bottom helpful dosage must be made use of, and various medications that have an effect on respiration must be averted. Get professional medical enable instantly in the not likely function that slow/shallow respiratory happens. Promethazine should not be used by youngsters with liver condition (which includes probable Reyes syndrome).
The phosphate salt of codeine happens as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in drinking water and slightly soluble in Liquor.